Nitrogen atomic radius is 56 pm, while it's covalent radius is 75 pm. Complete ground state electronic configuration for the Nitrogen atom, Unabbreviated electronic configuration. This unique reactivity is unlocked through the strategic use of a silyl group which acts as a reactivity-controlling element to suppress the inherent nucleophilicity of the nitrogen in indoles. Unabbreviated electronic configuration of neutral Nitrogen. Herein, we report the skeletal editing of indoles through nitrogen atom insertion, accessing their corresponding quinazoline or quinoxaline bioisosteres via trapping of an electrophilic nitrene species generated from ammonium carbamate and hypervalent iodine.

Late-stage remodeling strategies of widely encountered and pharmaceutically relevant scaffolds, such as indoles, would offer enormous potential to expand accessible chemical space. Nitrogen also has a direct toxic action of its own, affecting brain functions and inducing a stupor or euphoria. Five - membered heterocyclic ring contains at least one nitrogen atom as a ring. Here, the electron configuration of nitride ion(N 3) is 1s 2 2s 2 2p 6. In this case, the nitrogen atom carries a negative charge. The last shell of a nitrogen atom receives three electrons and turns into a nitride ion(N 3-). About 78 of Earth's atmosphere is nitrogen. Nitrogen has five electrons in its last orbit. Four representations chemists use for nitrogen molecules. Molecular nitrogen is a colorless, odorless, tasteless, and inert gas at normal temperatures and pressures. Although many peripheral late-stage transformations, mainly focusing on C–H functionalizations, have been reported, reliable strategies to directly edit the core skeleton of lead compounds have remained scarce. Nitrogen - containing alcohol, , inorganic alcoholate, or ether. Molecular nitrogen (N 2) is a very common chemical compound in which two nitrogen atoms are tightly bound together. Nitrogen atoms are ubiquitous in biologically significant secondary metabolites (alkaloids, cytokinins), biomacromolecules (proteins, peptides, DNA, RNA) as well as in synthetic organic substances, and commonly belong to atomic centers of importance for intra- and intermolecular interactions. Advances in the field of late-stage functionalization have expedited lead-structure discovery and established new opportunities to access valuable molecules.